D-8b-[(Methylthio)methyl]-6-propylergoline

Name	Pergolide
Synonyms	(6aR,9R) Pergolide PERGOLIDE Pergolide USP -9-((Methylthio) D-8b-[(Methylthio)methyl]-6-propylergoline Ergoline, 8-[(methylthio)methyl]-6-propyl-, (8b)- (9CI) -7-propyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline (6aR,9R)-9-((Methylthio)Methyl)-7-propyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline
CAS	66104-22-1
EINECS	200-110-4

Molecular Formula	C19H26N2S
Molar Mass	314.49
Density	1.124±0.06 g/cm3(Predicted)
Melting Point	207.5 °C
Boling Point	491.3±35.0 °C(Predicted)
pKa	17.66±0.40(Predicted)
Storage Condition	Sealed in dry,Store in freezer, under -20°C
Physical and Chemical Properties	Chemical properties solid, melting point 206-209 ℃. Pergolide mesylate (Pergolide Mesylate):C19H26N2S?CH4O3S. [66104-23-2]. Crystallization, melting point 225 ℃ (decomposition); Melting point 258~260 ℃. UV maximum absorption (water):279nm(ε6385);(methanol):280nm(ε6980);(anhydrous ethanol):281nm(ε6993). [α]D20-18.0 ~-23.0 (C = 10 mg/ml, dimethylformamide). pKa(66% dimethylformamide) 7.8. Insoluble in dimethylformamide or methanol, slightly soluble in water, 0.01mol/L hydrochloric acid, chloroform, acetonitrile, dichloromethane or anhydrous ethanol, very slightly soluble in acetone, almost insoluble in 0.1mol/L sodium hydroxide, 0.1mol/L hydrochloric acid or ether.
Use	The use of synthetic ergoline drugs, new dopaminergic agonists, its role is stronger, and long-acting. As an adjunctive therapeutic drug of levodopa and carbidopa, it is used for the treatment of Parkinson's disease. Antiparkinsonian drugs for the adjunctive treatment of Parkinson's disease

Raw Materials

Merck

14,7162

Last Update：2024-04-10 22:29:15

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CAS: 66104-22-1
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Raw Materials for D-8b-[(Methylthio)methyl]-6-propylergoline

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